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. 2018 May 14;9(5):577. doi: 10.1038/s41419-018-0529-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a U2OS cells expressing HA wild-type E2F7 (E2F7). E2F7 was detected using anti-HA antibody and endogenous UBF was detected with anti-UBF antibody. b U2OS cells expressing HA wild-type E2F7 (E2F7). Nucleophosmin was detected with anti-nucleophosmin antibody. c U2OS cells expressing HA wild-type E2F7 (E2F7) or double DNA-binding mutant R185A/R334A. Nucleolin was detected with anti-nucleolin antibody. d Diagram depicting a simplified model of UBF influence on Pol I activity resulting in increased pre-rRNA gene expression leading to enhanced protein synthesis. Elevated levels of perinucleolar E2F7 results in E2F7 binding to the rRNA promoter resulting in decreased pre-rRNA expression leading to decreased protein synthesis