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. 2018 May 15;4:23. doi: 10.1038/s41421-018-0020-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Hierarchial clustering analysis of global gene expression profiles to compare different passages of MHPCs with adult marmoset liver tissues. Passage 10, 25, and 30 MHPCs were used for RNA sequencing. M1 (male), M2, or F3 (female) refers to animal code. Expression levels (fold) are depicted in colors in which red represents upregulation and green means downregulation. b Semiquantitative RT-PCR analysis of hepatic progenitor cell markers for MHPCs at passage 30. Cav-1 refers to Caveolin-1; M2PK means tumor type M2 pyruvate kinase; Ccl2 chemokine (C-C motif) ligand 2; BMP4 bone morphogenetic protein 4; Cx-43 refers to Connexin 43. c Immunostaining of hepatic progenitor cell markers for MHPCs at passage 30. Nuclei was counterstained by DAPI (scale bar = 100 µm). d Gene set enrichment analysis (GSEA) of DNA replication and cell cycle-related genes for MHPCs at passage 30. DNA replication and cell cycle-related genes were significantly upregulated in MHPCs (passage 30) compared with adult marmoset liver tissues (n = 3, two-tailed t-test, *P < 0.1 × 10⁻⁴). e GSEA of cellular metabolism-related genes for MHPCs at passage 30. Cellular metabolism-related genes were significantly downregulated in MHPCs (passage 30) compared with adult marmoset liver tissues (n = 3, two-tailed t-test, *P < 0.1 × 10^-4)