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. 2018 May 14;9:1884. doi: 10.1038/s41467-018-04271-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Structure of a MACV GP1 CR1-07 Fab complex. a Top panel: Ribbon diagram of MACV GP1 (red) bound to the CR1-07 Fab (heavy chain in gray, light chain in blue). The antibody CDRs and GP1 segments involved in interactions are labeled. Bottom panel: Side view of the complex that allows better visualization of Fab-glycoprotein interactions. A site of N-linked glycosylation at Asn178 (for which we observed interpretable density) is shown. L: loop. LC: light chain. HC: heavy chain. Disulfides are shown as yellow sticks. b Overlay of the JUNV GP1/GD01 Fab structure (PDB: 5EN2)¹⁴ with the MACV GP1/CR1-07 Fab structure. The difference in the angle of Fab approach (from the perspective of the variable domain) is indicated and is similar for all copies in the ASU. c Surface representation of MACV GP1 (PDB: 3KAS)¹³ with segments from the CR1-07 Fab CDRs shown in cartoon representation. Residues that line the Tyr211_TfR1 pocket in MACV GP1 are shown in cyan and labeled. Two CDR H3 tyrosines that interact with pocket residues are shown as sticks. Asterisks indicate the two pocket residues that are conserved in JUNV and MACV GP1. For the other pocket residues, which differ between MACV and JUNV GP1, the amino acid found at the corresponding position in JUNV GP1 is shown in parentheses