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. 2018 May 8;9:304. doi: 10.3389/fneur.2018.00304

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Copyright © 2018 Doman, Girish, Nemeth, Drummond, Carr, Garcia, Johnston, Kannan, Fatemi, Zhang and Wilson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phase 3: T2 magnetic resonance imaging (MRI) scores at (A) 3 h or (B) 7 days after hypoxic ischemia (HI). At both MRI time points, we found a very strong correlation between MRI score and histopathologic brain injury at 7 days. However, inspection of the correlation plots reveals less sensitivity for detection of subtle injury in MRI scores at 7 days. MRI scores are generally lower at 7 days than at 3 h after HI, and the subtle atrophy that is detected by quantitative histopathology is not readily apparent in T2 MRI at 7 days. (Dashed lines show 95% confidence interval for the mean.)