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. 2018 May 8;6:48. doi: 10.3389/fcell.2018.00048

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Copyright © 2018 McCarthy, El-Ashry and Turley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hyaluronan is a large polymer during tissue homeostasis and fragmented in wounds and tumors. In homeostasis, large hyaluronan polymers are decorated by proteins/proteoglycans, which contribute to normal tissue architecture. (A) Cartoon of a virgin mouse mammary gland. (B) Cartoon of a mouse mammary tumor (Blue, mammary tumor cells). During wounding, fragmented hyaluronan polymers produced by ROS/hyaluronidases activate fibroblasts and attract immune cells, which contribute to the loss of tissue architecture.