Figure 1.

Overview of thymic γδT17 cell ontogeny. Initial intrathymic pathways leading to pre-committed γδT17 cells divergence from other T cell lineages are illustrated. The thymic (cortical and medullary) environmental cues involved in γδT17 cell effector fate and the preferential peripheral niches of mature γδ17 cells are also depicted. Labels indicate the cells, soluble factors, proteins, surface markers, and T cell receptor (TCR) signal strength involved in the γδT17 cell program of differentiation.