Figure 3.

An illustration of the EMT network. Attractor-preserving network reduction (Saadatpour et al., 2013) was applied to better focus attention on the most relevant nodes. Specifically, source nodes that represent input signals that are absent in the studied context are removed and each node with one input or one output is absorbed into its input or output, respectively. Nodes with light gray background are direct regulators of E-cadherin and nodes with dark gray background represent external signaling molecules. Edges ending with an arrow represent positive regulation while edges end with a flat bar represent negative regulation. See more details in Supplementary Material section 3.1.