Figure 12.

Other organ injury markers at 6 h. Urea: there was no detectable difference in urea concentration with an increasing dose of nucleic acid scavenging polymer (NASP) (hexadimethrine bromide) used in severe T-HS 25%. Creatinine: renal protection was evident with NASP 2 and 4 mg/kg doses. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST): there was a significant attenuation of liver injury evident with NASP 2 mg/kg dosing. Creatine kinase (CK): there was a significant attenuation of muscle injury with both NASP 1 and 2 mg/kg doses. Lactate: there was a significant reduction in 6 h lactate with all three doses NASP used. * denotes p < 0.05, † denotes p < 0.01 was untreated severe T-HS 25%, t-tests. n = 12–18 animals per group. Mean values with SEM bars shown. Overall, the NASP 2 mg/kg group produced the most consistent multiple organ protection in severe T-HS 25%.