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. 2018 May 8;9:901. doi: 10.3389/fmicb.2018.00901

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Copyright © 2018 Steglich, Hofmann, Helmecke, Sikorski, Spröer, Riedel, Bunk, Overmann, Neumann-Schaal and Nübel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of metabolic profiles from four isolates lacking the ABC transporter genes CDR20291_0805 and CDR20291_0806 and three wildtype isolates. Scatter plots of normalized peak areas are shown; left panel, intracellular metabolome; right panel, extracellular metabolome. Metabolites depleted or increased in deletion mutants by at least 1.5-fold with adjusted p-values < 0.01 are labeled in red and blue, respectively. (4-hydroxyphenyl)acetate and p-cresol are products from fermentation of tyrosine, and phenylacetate, 3-phenyllactate and 3-phenylpropanoate are products from fermentation of phenylalanine. All metabolomic data are provided in Supplementary Table S5.