Table 1.
Metabolic changes in isolates lacking ABC transporter genes CDR20291_0805 and CDR20291_0806 in comparison to “wildtype isolates.”
| Fold-change |
||
|---|---|---|
| Extracellular | Intracellular | |
| Tyrosine degradation | ||
| Tyrosine | 2.28 | 0.46 |
| (4-hydroxyphenyl)acetate | 0 | 0.26 |
| p-cresol | 0.15 | 0.54 |
| Phenylalanine degradation | ||
| Phenylalanine | (1.22)∗ | (0.92)∗ |
| Phenylacetate | 0.61 | 0.46 |
| 3-Phenyllactate | 0.59 | 0.58 |
| 3-Phenylpropanoate | 0.31 | 0.29 |
| Central carbon metabolism/other fermentation pathways | ||
| 2-Hydroxybutanoate | 2.60 | (0.91)∗ |
| Pyruvate | ND | 2.14 |
| Ribose | ND | 1.81 |
| 2-Oxoglutarate | ND | 2.64 |
| 3-Phosphoglycerate | ND | 2.18 |
| Isoleucine | (1.01)∗ | 0.65 |
Metabolites with fold-changes > 1.5 and adjusted p-values < 0.01 are shown. ND, not determined; ∗fold-change < 1.5.