Table 2.

Resting state magnetic resonance imaging (rsfMRI) studies of Internet Gaming Disorder (IGD).

Author	Sample	Aims	Findings
Xing et al. (36)	N = 34 adolescents in China (61% male; mean age = 19.1, SD = 0.7 years)	To assess the relationship between the salience network and cognitive control in adolescents with IGD	Right salience network associated with impaired executive function. Structural connectivity differences between adolescents with IGD and healthy controls.
Yuan et al. (38)	N = 87 adolescents and young adults in China (75% male; mean age = 19, SD = 1.4 years, range = 15–23)	To assess differences in striatum volume and resting-state functional connectivity (RSFC) networks between individuals with IGD and healthy controls	Differences in striatum volume and frontostriatal circuits RSFC between individuals with IGD and healthy controls. Cognitive control deficits in IGD correlated with reduced frontostriatal RSFC strength.
Yuan et al. (33)	N = 33 young male gamers and non-gamers in Germany (mean age = 25.5, SD = 4.2, range = 18–34)	To assess whether World of Warcraft layers have deficient reward system	Evidence for reward system deficiency in frequent online gamers, including significantly decreased neural activation during anticipation of small and large monetary rewards in ventral striatum
Lin et al. (34); Lin et al. (35)	N = 52 male young individuals in China (mean age = 22.2, SD = 3.1 years)	To assess abnormal spontaneous brain activity in IGD with low-frequency fluctuation (fALFF) at different frequency bands	Individuals with IGD had lower fALFF values in superior temporal gyrus and higher fALFF values in cerebellum
Wang et al. (39)	N = 41 adolescents in China (mean age = 16.9, SD = 2.7 years; range = 14–17)	To assess interhemispheric resting state functional connectivity of individuals with IGD using voxel-mirrored homotopic connectivity (VMHC)	Individuals with IGD had decreased VMHC between orbital part of left and right superior, middle and inferior frontal gyrus