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. 2018 May 8;9:908. doi: 10.3389/fmicb.2018.00908

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Copyright © 2018 Yuan, Liu, Zhang, Li, Zhang, Wu, Chen, Cao, Hou, Zhang, Zhu, Yuan, Tang, Cheng and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of hiPSC-HLCs and hHLC-FRGS mice supporting HBV infection. hiPSCs were induced to differentiate to hepatocyte-like cells (HLCs). The hHLCs are characterized by examining their expression of hALB, hAAT, hRXR, hNTCP, and hHNF4α. This study included the generation and characterization of hiPSC-HLCs, the maintenance of long-term hepatic differentiation state and in vitro HBV infection, generation of human liver chimeric hHLC-FRGS mice by hiPSC-HLCs engraftment, establishment of chronic HBV infection.