FIG 1.

Phylogenetic status of modern CV-A6 strains. (A) Neighbor-joining tree based on a short region of the CV-A6 genome (partial VP1, positions 2614 to 2866, corresponding to the Gdula genome). Only topology is shown for clear demonstration of phylogenetic relationships between strains. (B and C) Neighbor-joining tree based on full-length CV-A6 genomes. Prototypes of the HEV-A group, EV-D68, and poliovirus 1 were used as references. The tree indicates that modern CV-A6 strains are phylogenetically close to the prototype Gdula (B), while the subtree indicates that strains from Changchun have different origins (C). All the trees were tested by the bootstrap method for 1,000 replicates, and values of >70 are shown at the nodes. ●, CV-A6-Changchun isolates.