FIG 6.

Similarity tests and bootscanning analyses of the CV-A6-Changchun strains and the prototype Gdula and CV-A4 on the basis of full-length genomes. The similarity tests for Changchun046 (A), Changchun097 (C), Changchun099 (E), and Changchun098 (G) were performed with prototypic strains of members of the HEV-A group. The test results indicated that modern CV-A6 strains circulating in Changchun were mostly recombinants between CV-A6 and CV-A4, as previously described (16, 17). Thus, for better demonstration, only CV-A4 (accession number AY421762) and CV-A6 Gdula (accession number AY421764) were included as the reference sequences for the bootscanning tests for Changchun046 (B), Changchun097 (D), Changchun099 (F), and Changchun098 (H). EV-D68 (accession number AY426531) and poliovirus 1 (accession number V01150) were used as the outliers in both similarity tests and bootscanning analyses. All the tests were performed with full-length viral genomes. A cartoon of the enteroviral genome is shown at the top.