FIG 5.

CyPB activity modestly accelerates HPV16 internalization. (A) Amino acid sequences of the putative L2 CyPB binding motif (HPV16 versus HPV16 L2-GP-N). (B) The infectious internalization kinetics of HPV16 (black) and HPV16 L2-GP-N (dark gray) were compared in add-on experiments (as described for Fig. 3A). (C) Infectious internalization of HPV16 (black) and HPV16 L2-GP-N (dark gray) was analyzed in seed-over experiments (as described for Fig. 3B). (D) The infectious internalization kinetics of FPC-HPV16 (white) and FPC-HPV16 L2-GP-N (light gray) were compared in add-on experiments. (E) Infectious internalization of FPC-HPV16 HPV16 (white) and HPV16 L2-GP-N (light gray) were analyzed in seed-over experiments. Infectious internalization values are shown relative to 48-h infection samples in percentages ± SD for all experiments.