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. 2018 May 14;92(11):e02141-17. doi: 10.1128/JVI.02141-17

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Copyright © 2018 Law et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — ΔHVR1 gpE1/gpE2 antigen elicits similar neutralization responses to homologous and heterologous HCVpp in vaccinated guinea pigs. Prevaccination or terminal-bleed antisera from control (C) or WT or ΔHVR1 gpE1/gpE2-vaccinated guinea pigs were examined for neutralization activity. (A) Neutralization of HCVpp pseudotyped with homologous H77C (Gt1a) gpE1/gpE2 at a 1/100 serum dilution (left) and half-maximal inhibitory concentrations (IC₅₀) determined by 2-fold serial dilutions from 1/200 to 1/12,800 (right). (B) Neutralization of heterologous HCVpp pseudotyped with S52 (Gt3a), ED43 (Gt4a), or SA13 (Gt5a) gpE1/gpE2 at a 1/100 serum dilution. Neutralization activity was normalized to the luciferase level obtained by using preimmunized sera. *, P < 0.05 by one-way analysis of variance with a Tukey post hoc test. Only statistically significant differences are highlighted. Comparison of the neutralization activities of WT and ΔHVR1 gpE1/gpE2 antigens against S52/ED43/SA13 HCVpp-immunized guinea pigs showed no significant difference.