TABLE 1.
MAb | Protein target | Conformation dependence | Critical binding residuesa | Reference |
---|---|---|---|---|
H77.16 | E2 | No | 405, 406, 408, 410 | 52 |
AP33 | E2 | No | 413, 415, 418, 420 | 56 |
HC33.1 | E2 | No | 413, 414, 418, 420 | 55 |
FC33.4 | E2 | No | 408, 413, 418, 420 | 55 |
HC84.26 | E2 | Yes | 429, 441, 442, 443, 446, 616 | 53 |
AR3b | E2 | Yes | 412, 416, 418, 423, 424, 523, 525, 530, 535, 540 | 16 |
AR4a | E1E2 | Yes | 201, 204, 205, 206, 487, 657, 658, 692, 698 | 54 |
AR5a | E1E2 | Yes | 201, 204, 205, 206, 639, 657, 658, 665, 692 | 54 |
Based on H77C polyprotein numbering (residues 192 to 383 for E1 and 384 to 746 for E2). (Adapted from reference 50.)