Table 1.
Description of PSR and selection criteria.
| Selection criteria | UniProt Entry name | Protein name | Gene |
|---|---|---|---|
| Group 1: Differentially expressed proteins (DEPs) from studies on OC cell lines (A2780) treated with PMX | HS90A_HUMAN | Heat shock protein HSP90-alpha | HSP90AA1 |
| TRAP1_HUMAN | Heat shock protein 75 kDa, mitochondrial; tumor necrosis factor (TNF) receptor-associated protein 1 | TRAP1 | |
| MOS_HUMAN | Proto-oncogene serine/threonine-protein kinase mos | MOS | |
| PTBP1_HUMAN | Polypyrimidine tract-binding protein 1 | PTBP1 | |
| NDKB_HUMAN | Nucleoside diphosphate kinase B | NME2 | |
| NDKA_HUMAN | Nucleoside diphosphate kinase A | NME1 | |
| Group 2.i: Folate related proteins and proteins target of PMX | TYSY_HUMAN | Thymidylate synthase | TYMS |
| DYR_HUMAN | Dihydrofolate reductase | DHFR | |
| FOLC_HUMAN | dihydrofolate synthase/Folylpolyglutamate synthase, mitochondrial | FPGS | |
| GGH_HUMAN | Gamma-glutamyl hydrolase | GGH | |
| PUR2_HUMAN | Trifunctional purine biosynthetic protein adenosine-3; glycinamide ribonucleotide formyltransferase | GART | |
| PUR9_HUMAN | Bifunctional purine biosynthesis protein PURH; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | ATIC | |
| Group 2.ii: Other proteins connected to PMX | DCK_HUMAN | Deoxycytidine kinase\ | DCK |
| S29A1_HUMAN | Equilibrative nucleoside transporter 1 | SLC29A1 | |
| Group 2.iii: Proteins derived from gene analysis studies on the response to PMX in platinum-resistant OC patients | ERCC1_HUMAN | DNA excision repair protein ERCC-1; excision repair cross-complementation group 1 | ERCC1 |
| FOLR1_HUMAN | Folate receptor 1, alpha | FOLR1 | |
| RFC1_HUMAN | Replication factor C subunit 1 | RFC1 | |
| GSTP1_HUMAN | Glutathione S-transferase Pi 1 | GSTP1 | |
| PCFT_HUMAN | Proton-coupled folate transporter | SLC46A1 | |
| Group 2.iv: Proteins associated with platinum and multidrug resistance | MRP1_HUMAN | Multidrug resistance-associated protein 1 | ABCC1 |
| MDR1_HUMAN | Multidrug resistance protein 1 | ABCB1 | |
| TOP2A_HUMAN | DNA topoisomerase II-alpha | TOP2A | |
| TOP1_HUMAN | DNA topoisomerase I | TOP1 | |
| CALD1_HUMAN | Caldesmon 1 | CALD1 | |
| PAX8_HUMAN | Paired box protein Pax-8 | PAX8 | |
| MGMT_HUMAN | Methylated-DNA–protein-cysteine methyltransferase | MGMT | |
| VDAC1_HUMAN | Voltage-dependent anion-selective channel protein 1 | VDAC1 | |
| PPIA_HUMAN | Peptidyl-prolyl cis-trans isomerase A | PPIA |