Table 3.
Final panel of 24 proteins: function and involvement in cancer mechanisms.
| UniProt entry name | Protein name | Gene | PANTHER GO-slim biological process | CR/NR* | PR/NR* |
|---|---|---|---|---|---|
| AKT1_HUMAN | RAC-alpha serine/threonine-protein kinase | AKT1 | biological regulation | 0.52 | 0.93 |
| BAX_HUMAN | Apoptosis regulator BAX | BAX | apoptotic process biological regulation cellular component organization or biogenesis | 3.90 | 4.76 |
| CYC_HUMAN | Cytochrome c | CYCS | apoptotic process biological regulation | 1.29 | 1.91 |
| GSHR_HUMAN | Glutathione reductase, mitochondrial | GSR | protein metabolic process | 1.58 | 2.52 |
| GSTP1_HUMAN | Glutathione S-transferase Pi 1 | GSTP1 | PantherDB: unclassified | 1.19 | 2,.18 |
| HXK2_HUMAN | Hexokinase-2 | HK2 | biological regulation | 1.17 | 2.04 |
| IBP3_HUMAN | Insulin-like growth factor-binding protein 3 | IGFBP3 | biological regulation | 1.58 | 1.63 |
| K1C19_HUMAN | Keratin, type I cytoskeletal 19 | KRT19 | cellular component organization or biogenesis | 2.27 | 2.36 |
| PCNA_HUMAN | Proliferating cell nuclear antigen | PCNA | biological regulation DNA metabolic process DNA replication | 1.81 | 1.36 |
| PDCD6_HUMAN | Programmed cell death protein 6 | PDCD6 | proteolysis protein metabolic process | 207 | 2.88 |
| RSSA_HUMAN | 40S ribosomal protein SA | RPSA | cellular component organization or biogenesis protein metabolic process | 0.98 | 1.65 |
| STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | STAT1 | biological regulation | 19.29 | 11.03 |
| TRAP1_HUMAN | Heat shock protein 75 kDa, mitochondrial; tumor necrosis factor (TNF) receptor-associated protein 1 | TRAP1 | protein metabolic process | 2.77 | 1.95 |
| THIO_HUMAN | Thioredoxin | TXN | biological regulation protein metabolic process | 0.59 | 2.68 |
| ACTB_HUMAN | Actin, cytoplasmic 1 | ACTB | cell cycle cellular component organization or biogenesis | 12.74 | 26.32 |
| AIFM1_HUMAN | Apoptosis-inducing factor 1, mitochondrial | AIFM1 | protein metabolic process | 4.20 | 2.38 |
| PLMN_HUMAN | Plasminogen | PLG | proteolysis protein metabolic process | 2.33 | 0.82 |
| TF65_HUMAN | Transcription factor p65 | RELA | biological regulation | 0.11 | 1.35 |
| TYSY_HUMAN | Thymidylate synthase | TYMS | PantherDB: unclassified | — | — |
| DRY_HUMAN | Dihydrofolate reductase | DHFR | PantherDB: unclassified | — | — |
| PUR2_HUMAN | Trifunctional purine biosynthetic protein adenosine-3; glycinamide ribonucleotide formyltransferase | GART | purine nucleobase metabolic process | 2.07 | 2.34 |
| CD158_HUMAN | Coiled-coil domain-containing protein 158 | CCDC158 | cell cycle | <3.6 × 10−6 | >1.1 × 10−3 |
| P66A_HUMAN | Transcriptional repressor p66-alpha | GATAD2A | PantherDB: unclassified | >1.4 × 106 | >0.7 × 106 |
| PRS7_HUMAN | Proteasome 26S protease regulatory subunit 7 | PSMC2 | cellular component organization or biogenesis proteolysis protein metabolic process | >1.5 × 106 | >3.0 × 106 |
*
Abundance ratio; CR, complete responder; PR, partial responder; NR, non-responder.