Table 2.
The positive result summary of module enrichment analysis.
| Module ID | Seed gene group | Number of genes | p-value | Proportion |
|---|---|---|---|---|
| 146 | Anxiety (D) | 13 | 2.90E-06 | 4.770082 |
| 146 | Chest pain (S) | 25 | 0.0221 | 1.38308 |
| 146 | Dizziness (S)) | 28 | 0.012776 | 1.429755 |
| 146 | Insomnia (S) | 8 | 0.00495 | 2.877702 |
| 146 | Palpitations (S) | 12 | 1.27E-09 | 10.55632 |
| 146 | Shortness of breath (S) | 5 | 0.033574 | 2.538544 |
| 146 | Thirst (S) | 23 | 5.05E-16 | 9.163804 |
| 146 | Pinellia Tuber(Ban Xia) | 25 | 1.40E-05 | 2.487102983 |
| 146 | Poria coco(Fu Ling) | 8 | 0.041464852 | 1.821802935 |
| 146 | Diseases | 14 | 0.000434 | 3.083373 |
| 146 | Herbs | 34 | 0.002613 | 1.809648 |
| 146 | Symptoms | 57 | 9.68E-06 | 2.129997 |
| M146 | Positive results | 12 | ||
| 203 | Arrhythmia (D) | 3 | 0.005047 | 8.311160088 |
| 203 | Autonomic dysfunction (D) | 1 | 0.015491 | 63.71889401 |
| 203 | Chest pain (S) | 8 | 0.013648 | 2.270036 |
| 203 | Dizziness (S) | 9 | 0.00725 | 2.357119 |
| 203 | Palpitations (S) | 2 | 0.019188 | 9.023954 |
| 203 | Thirst (S) | 3 | 0.011237 | 6.130623 |
| 203 | Diseases | 5 | 0.002451 | 6.064949 |
| 203 | Symptoms | 13 | 0.006585 | 2.732289 |
| M203 | Positive results | 8 | ||
| 194 | Chest pain (S) | 9 | 0.000671 | 3.298646 |
| 194 | Dizziness (S) | 9 | 0.001176 | 3.044612 |
| 194 | Insomnia (S) | 3 | 0.007411 | 7.149291 |
| 194 | Symptoms | 12 | 0.001491 | 3.783921 |
| M194 | Positive results | 4 | ||
| 195 | Chest pain (S) | 4 | 0.049971 | 2.513254 |
| 195 | Symptoms | 7 | 0.014961 | 3.779208 |
| M195 | Positive results | 2 | ||
| 204 | Cardiac sympathetic remodeling (D) | 1 | 0.049286 | 19.47464789 |
| 204 | Dizziness (S) | 24 | 0.025127 | 1.37222 |
| M204 | Positive results | 2 | ||
| 95 | Chest pain (S) | 3 | 0.020438 | 4.398194 |
| M95 | Positive results | 1 |
The positive result summary of module enrichment analysis between 8 CHD modules and the seed gene groups for Chinese herbs, co-morbid diseases, and co-morbid symptoms, calculated both collectively and separately. In modular ID column, the numbers refer to CHD module number. In the seed gene group column, (S) denotes single co-morbid symptom while (D) denotes single co-morbid disease, “diseases” denotes all co-morbid diseases, “herbs” denotes all LXNX formula herbs, and “symptoms” denotes all co-morbid symptoms. In the positive results rows, the number shown means positive result count number related to that specific CHD module shown on the left.