Table 3.

The functional pathway analysis of CHD modules related to LXNX formula.

Modular ID	Category	Term	Number of pathway gene	Number of key protein
146	KEGG_PATHWAY	hsa04080:Neuroactive ligand-receptor interaction	42	17
146	KEGG_PATHWAY	hsa04024:cAMP signaling pathway	29	14
146	GOTERM_BP_DIRECT	GO:0007189∼adenylate cyclase-activating G-protein coupled receptor signaling pathway	34	20
146	GOTERM_BP_DIRECT	GO:0030819∼positive regulation of cAMP biosynthetic process	30	10
146	GOTERM_BP_DIRECT	GO:0007190∼activation of adenylate cyclase activity	27	17
146	GOTERM_BP_DIRECT	GO:0007186∼G-protein coupled receptor signaling pathway	56	15
146	GOTERM_BP_DIRECT	GO:0007188∼adenylate cyclase-modulating G-protein coupled receptor signaling pathway	19	10
146	GOTERM_BP_DIRECT	GO:0006171∼cAMP biosynthetic process	14	10
146	GOTERM_BP_DIRECT	GO:0019933∼cAMP-mediated signaling	14	10
146	GOTERM_BP_DIRECT	GO:0007193∼adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	13	9
203	GOTERM_BP_DIRECT	GO:0044267∼cellular protein metabolic process	16	3

In the module ID column, the numbers denote numbers of CHD modules related to LXNX formula. In the category column, KEGG-PATHWAY refers to the pathway enrichment analysis, and GOTERM_BP_DIRECT refers to the GO term enrichment analysis. In the term column, the text indicates results of function enrichment analysis corresponding to the type of analysis shown on the left. In the number of pathways gene column, the numbers refer to the gene count numbers corresponding to the pathway on the left. In the number of key protein column, the numbers refer to the protein count numbers of key drug targets in the corresponding pathway on left.