. 2018 Apr 17;7(5):663–672. doi: 10.1530/EC-18-0089
This work is licensed under a Table 3.
Anthropometric, metabolic, and psychiatric parameters of patients with Prader–Willi syndrome according to GH treatment in childhood and transition status.
| Group not treated by GH (n = 61) | Group treated by GH (n = 34) | |||||
|---|---|---|---|---|---|---|
| Transition (n = 12) | No transition (n = 49) | P | Transition (n = 19) | No transition (n = 15) | P | |
| Age (year) | 25.7 ± 5.8 | 32.8 ± 9.8 | 0.02 | 23.2 ± 3.8 | 28.7 ± 6.3 | <0.01 |
| Female gender | 7 (58.3) | 30 (61.2) | 1 | 10 (52.6) | 4 (26.7) | 0.24 |
| Weight (kg) | 83.3 ± 18.6 | 104.8 ± 32.9 | 0.03 | 78.0 ± 19.4 | 102.0 ± 27.8 | <0.01 |
| Height (cm) | 152 ± 8 | 152 ± 12 | 0.96 | 160 ± 11 | 160 ± 9 | 0.88 |
| BMI (kg/m2) | 35.9 ± 7.9 | 44.7 ± 12.7 | 0.03 | 30.4 ± 7.1 | 39.2 ± 10.2 | <0.01 |
| Obesity | 9 (75.0) | 39 (79.6) | 0.82 | 9 (47.4) | 11 (73.3) | 0.14 |
| Grade III obesity (%) | 5 (41.7) | 31 (63.3) | 0.22 | 2 (10.5) | 8 (53.3) | <0.01 |
| Body composition | ||||||
| Fat mass (%) | 51.0 ± 4.0 | 51.5 ± 5.6 | 0.80 | 44.9 ± 7.2 | 49.2 ± 6.9 | 0.11 |
| Fat mass (kg) | 39.5 ± 9.4 | 53.8 ± 19.0 | 0.01 | 34.5 ± 10.9 | 47.6 ± 14.7 | <0.01 |
| Lean body mass (kg) | 37.9 ± 7.7 | 47.2 ± 13.0 | 0.02 | 39.2 ± 9.3 | 47.7 ± 11.9 | 0.03 |
| Fat mass index (kg/m2) | 17.0 ± 3.6 | 23.1 ± 7.5 | <0.01 | 13.7 ± 4.8 | 18.7 ± 6.4 | 0.02 |
| Trunk fat mass/appendicular fat mass | 0.9 ± 0.2 | 1.0 ± 0.2 | 0.30 | 0.8 ± 0.3 | 1.0 ± 0.3 | 0.02 |
| Metabolic parameters | ||||||
| Type 2 diabetes | 4 (33.3) | 18 (36.7) | 1 | 2 (10.5) | 3 (15.8) | 0.70 |
| High blood pressure* | 1 (8.3) | 13 (26.5) | 0.30 | 0 | 2 (13.3) | 0.32 |
| Behavior | ||||||
| Neuroleptic treatment | 7 (58.3) | 27 (55.1) | 1 | 3 (15.8) | 8 (53.3) | 0.03 |
| Antidepressant treatment | 3 (25.0) | 16 (32.7) | 0.80 | 1 (5.3) | 9 (60.0) | <0.001 |
| Hospitalization in psychiatry | 2 (16.7) | 16 (32.7) | 0.41 | 4 (21.1) | 6 (31.6) | 0.26 |
*Systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg. The fat mass index was calculated as fat mass in kg divided by height squared (kg/m2).