Figure 9.

Naloxone reduced TNF-α secretion from CD11b⁺ cells. A, LPS induced TNF-α secretion from CD11b-expressing cells isolated from the infarct area of rat brain 7 d after dMCAo. **, p < 0.01, Mann–Whitney U test; control n = 6, LPS n = 5 in 2 independent experiments. B, CD11b⁺ cells were isolated from the infarct area and treated with different concentrations of naloxone as indicated for 20 h. *, p < 0.05 and **, p < 0.01 indicate pairwise comparison with the control group by Dunnett’s post hoc test following one-way ANOVA; control n = 9, naloxone n = 8–9 in 3 independent experiments. The culture medium was analyzed using TNF-α ELISA. The data represent mean ± SEM.