Table 1.

Genes Involved in Mitochondrial Function from the Aging-Related Turquoise Module

KEGG pathway	Gene symbol	GSa.Age	pb.GS.Age	MMc.turquoise	p.MM.turquoise
TCA cycle	DLD	−0.26	3.69 × 10−6	0.90	9.36 × 10−110
	PDHB	−0.21	2.05 × 10−4	0.79	1.64 × 10−64
	DLAT	−0.20	4.16 × 10−4	0.79	2.37 × 10−65
	SDHC	−0.20	0.001	0.86	9.23 × 10−88
	OGDH	−0.18	0.002	0.71	5.85 × 10−47
	FH	−0.16	0.005	0.87	5.69 × 10−94
	IDH2	−0.15	0.008	0.52	5.38 × 10−22
	SDHA	−0.14	0.019	0.60	3.03 × 10−30
	MDH1	−0.13	0.021	0.76	1.13 × 10−57
	ACO2	−0.11	0.066	0.69	2.27 × 10−44
	PDHA1	−0.08	0.150	0.57	1.88 × 10−27
OXPHOS	FADD	−0.30	8.13 × 10−8	0.67	9.84 × 10−41
	GSK3B	−0.28	6.55 × 10−7	0.69	3.64 × 10−43
	NDUFS1	−0.21	2.95 × 10−4	0.87	1.64 × 10−92
	SDHC	−0.20	0.001	0.86	9.23 × 10−88
	NDUFV3	−0.19	0.001	0.64	1.56 × 10−36
	ATP5A1	−0.19	0.001	0.84	6.39 × 10−80
	UQCRFS1	−0.17	0.003	0.89	3.20 × 10−103
	NDUFA9	−0.14	0.017	0.79	1.05 × 10−65
	SDHA	−0.14	0.019	0.60	3.03 × 10−30
	ATP5F1	−0.14	0.020	0.79	4.65 × 10−64
	MAPK1	−0.11	0.054	0.71	3.25 × 10−47
	UQCRC2	−0.11	0.060	0.69	1.63 × 10−43
	NDUFB5	−0.11	0.062	0.52	1.07 × 10−21
	ATP5C1	−0.11	0.071	0.76	3.48 × 10−57
	ATP5B	−0.10	0.074	0.82	5.72 × 10−74
	IDE	−0.10	0.082	0.68	1.35 × 10−41
	EIF2AK3	−0.08	0.155	0.61	2.03 × 10−31
	NDUFV2	−0.06	0.286	0.70	2.42 × 10−45

^aGS indicates gene significance, which denotes correlation between each gene and age.

^bp. denotes Pearson's correlation coefficient p-values.

^cMM indicates module membership, which denotes correlation between each gene and module eigengene.

KEGG, Kyoto Encyclopedia of Genes and Genomes; OXPHOS, oxidative phosphorylation; TCA, tricarboxylic acid.