Table 3.

Genes Involved in the Immune Response from the LT-Related Tan Module

KEGG pathway	Gene symbol	GSa.Age	pc.GS.Age	MMc.tan	p.MM.tan
T-cell receptor signaling pathway	ITK	0.29	2.16 × 10−7	0.83	2.76 × 10−78
	ZAP70	0.26	6.83 × 10−6	0.9	1.88 × 10−106
	CD247	0.24	3.14 × 10−5	0.9	1.88 × 10−107
	PTPRC	0.2	4.16 × 10−4	0.87	9.84 × 10−95
	PDCD1	0.2	4.31 × 10−4	0.68	8.70 × 10−43
	RASGRP1	0.2	0.001	0.9	1.43 × 10−110
	GRAP2	0.18	0.002	0.86	8.31 × 10−89
	CD8A	0.17	0.003	0.72	6.64 × 10−49
	CD8B	0.17	0.004	0.73	3.11 × 10−50
	CARD11	0.17	0.004	0.91	6.96 × 10−113
	ICOS	0.16	0.006	0.84	9.16 × 10−81
	LCK	0.16	0.005	0.9	1.34 × 10−107
	CTLA4	0.14	0.015	0.78	2.16 × 10−63
	CD28	0.11	0.064	0.83	9.08 × 10−76
	CD3D	0.03	0.573	0.84	6.08 × 10−81
Autoimmune thyroid disease	CTLA4	0.14	0.015	0.78	2.16 × 10−63
	FASLG	0.12	0.042	0.67	1.01 × 10−40
	CD28	0.11	0.064	0.83	9.08 × 10−76

^aGS indicates gene significance, which denotes correlation between each gene and age.

^bp. denotes Pearson's correlation coefficient p-values.

^cMM indicates module membership, which denotes correlation between each gene and module eigengene.