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. 2018 Mar 15;30:248–260. doi: 10.1016/j.ebiom.2018.03.010

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 3 — Identification of differentially expressed adipocyte specific lncRNAs in insulin resistance individuals versus insulin sensitive individuals. A. ROC curve of 16 intergenic lncRNAs that were significantly regulated in WAT of obese insulin resistant individuals. B. Analysis of cell type specific expression in WAT for the 10 differentially regulated lncRNAs genes regulated in obese WAT using Real-time PCR. n = 11 per group, # SVF versus WAT, significant enrichment in the SVF compared to the MA fraction is indicated by #, ^#p < 0.05, ^##p < 0.01. See legend to Fig. 2 for an explanation of symbols. For lncRNA ENSG00000229961.1, ENSG00000250237.1 and ENSG00000256551.1, we could not detect the expression. C. Analysis of expression during human adipose tissue-derived stem cells (hADSCs) over in vitro differentiation to adipocytes for the 8 lncRNAs regulated in WAT of obese insulin resistance individuals by CAGE. The CAGE data for CATG00000111229.1 and ENSG00000235609.4 are in Fig. 2C. The expression of the other 6 lncRNAs was not detected by CAGE.