Fig. 4.

Identification of adipocyte specific lncRNAs associated with insulin resistance. A. Venn diagram (left panel) of the overlap of affected lncRNAs in obese versus lean and obese insulin resistant versus insulin sensitive subjects; the detailed information for the 3 overlapped lncRNAs are presented in the table (right panel). B. Dot plot demonstrating the correlation between the expression of 3 lncRNAs and 4 selected clinical parameters insulin stimulated lipogenesis, basal lipogenesis, basal lipolysis and lipolysis stimulated by a catecholamine (Isoprenaline) in the lean vs obese cohort, respectively. Regression lines for each sample group were added. C. Heatmap of correlations with p-values in parentheses between modules and clinical parameters. Degrees of associations are indicted by colours, positive correlation, red; negative correlation, blue; no correlation, white. D. Bar plots showing the pathways characterized in mouse phenotypes for highly positive correlated genes with our selected lncRNAs within each module (indicated by bar colour).