Previously recognized de novo and salvage pathways for NAD+ biosynthesis. Dotted boxes show compounds that can be taken up by the cell. ADPR-PPase, ADP-ribose pyrophosphatase; DHAP, dihydroxyacetone phosphate; Na, nicotinic acid; NaAD, nicotinic acid adenine dinucleotide; NaMN, nicotinic acid mononucleotide; NaMNAT, nicotinic acid mononucleotide adenylyltransferase; NaPRT, nicotinic acid phosphoribosyltransferase; NaR, nicotinic acid riboside; Nm, nicotinamide; NMN, nicotinamide mononucleotide; NMNAT, nicotinamide mononucleotide adenylyltransferase; NmPRT, nicotinamide phosphoribosyltransferase; NmR, nicotinamide riboside; PRPP, phosphoribosyl pyrophosphate; Qa, quinolinic acid; QaPRT, quinolinic acid phosphoribosyltransferase; R5P, ribose 5-phosphate.