Fig. 2.

Metformin decreases the expression of lipid de novo synthesis-related genes in HepG2 cells exposed to high glucose and high insulin. a and b Metformin decreases the protein expression of SCD1 in HepG2 cells exposed to high glucose and high insulin. The data are presented as the means ± SEM, n = 3. ^**p < 0.01, versus NC; ^#p < 0.05, versus HGHIn. c Metformin decreases the mRNA expression of FAS and SCD1 in HepG2 cells exposed to high glucose and high insulin. The data are presented as the means ± SEM, n = 4. ^*p < 0.05 and ^**p < 0.01, versus NC; ^##p < 0.01, versus HGHIn. NC normal control, HGHIn high glucose high insulin; Met metformin