Fig. 4.

Metformin inhibits the transcriptional activity of the SCD1 promoter in HepG2 cells. a The SCD1 promoter between both − 920/+ 199 and − 550/+ 199 is inhibited by metformin, and the element responsible for metformin functionis in − 550/+ 199. The data are presented as the means ± SEM, n = 3. ^**p < 0.01, versus control in SCD1 promoter of − 920/+ 199; ^##p < 0.01, versus control in SCD1 promoter of − 550/+ 199