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. 2018 May 14;17:114. doi: 10.1186/s12944-018-0762-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Proposed working model. High glucose and high insulin promote the expression of SCD1, which leads to increased TG accumulation in hepatocytes. Metformin inhibits the transcriptional activity of the SCD1 promoter, thus decreasing the expression of SCD1, which leads to reduced TG accumulation in hepatocytes. The AMPK-SREBP-1c pathway may be involved in the regulation of the transcriptional activity of the SCD1 promoter by metformin