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Effects of astragalosides on ECM factors in HSC induced by TGF-β1. By assay of ELISA, AST was found to inhibit collagen accumulation and the expression of MMP-2 and TIMP-2 (a), and the results of real-time PCR showed the same trend (b). AST: astragalosides; LY-364947: TGF-β receptor 1 inhibitor. The values presented are the means ± SD (n = 5 in each group). P < 0.05 and ∗∗P < 0.01 versus control group; P < 0.05 and ##P < 0.01 versus model group (TGF-β1).
