Table 7.
Correlation between autoantibodies and quantitative ultrasound index (QUS index): univariate analysis.
| Autoantibody | Model 1 (autoantibody alone) [coefficient; (95% CI); p value] |
Model 2a (autoantibody alone, females only) [coefficient; (95% CI); p value] |
Model 2b (autoantibody alone, males only) [coefficient; (95% CI); p value] |
|---|---|---|---|
| ANA borderline | −0.11 | −0.18 | −0.13 |
| (−0.26; 0.05) | (−0.22; 0.18) | (−0.36; 0.10) | |
| p = 0.168 | p = 0.857 | p = 0.267 | |
| n = 1628 | n = 749 | n = 879 | |
|
| |||
| ANA positive | −0.20 | −0.15 | −0.16 |
| (−0.40; 0.00) | (−0.40; 0.09) | (−0.47; 0.15) | |
| p = 0.046 | p = 0.228 | p = 0.304 | |
| n = 1628 | n = 749 | n = 879 | |
|
| |||
| Anti-ENA autoantibodies borderline | 0.55 | 0.80 | 0.27 |
| (−0.38; 1.49) | (−0.25; 1.84) | (−1.38; 1.91) | |
| p = 0.245 | p = 0.135 | p = 0.749 | |
| n = 877 | n = 442 | n = 435 | |
|
| |||
| Anti-ENA autoantibodies positive | −0.39 | −0.21 | −0.59 |
| (−0.99; 0.20) | (−0.86; 0.43) | (−1.70; 0.51) | |
| p = 0.194 | p = 0.516 | p = 0.291 | |
| n = 877 | n = 442 | n = 435 | |
|
| |||
| ANCA borderline | −0.02 | −0.04 | 0.01 |
| (−0.21; 0.18) | (−0.29; 0.21) | (−0.27; 0.30) | |
| p = 0.868 | p = 0.744 | p = 0.922 | |
| n = 1621 | n = 743 | n = 878 | |
|
| |||
| ANCA positive | −0.19 | 0.12 | −0.50 |
| (−0.45; 0.07) | (−0.18; 0.42) | (−0.93; −0.05) | |
| p = 0.160 | p = 0.441 | p = 0.028 | |
| n = 1621 | n = 743 | n = 878 | |
|
| |||
| Anti-TPO autoantibodies positive | −0.21 | −0.18 | −0.11 |
| (−0.46; 0.04) | (−0.47; 0.10) | (−0.55; 0.33) | |
| p = 0.100 | p = 0.201 | p = 0.618 | |
| n = 2114 | n = 1011 | n = 1099 | |
|
| |||
| Anti-RHF autoantibodies positive | 0.45 | 0.31 | 0.76 |
| (−0.44; 1.34) | (−0.68; 1.30) | (−0.80; 2.32) | |
| p = 0.325 | p = 0.536 | p = 0.338 | |
| n = 1947 | n = 931 | n = 1012 | |
|
| |||
| Anti-TTG autoantibodies positive | −0.15 | −0.02 | −0.28 |
| (−0.44; 0.14) | (−0.42; 0.37) | (−0.69; 0.14) | |
| p = 0.306 | p = 0.902 | p = 0.192 | |
| n = 2114 | n = 1011 | n = 1099 | |
|
| |||
| Anti-CCP autoantibodies positive | −043 | −0.39 | −0.61 |
| (−1.51; 0.65) | (−2.11; 1.33) | (−2.03; 0.81) | |
| p = 0.437 | p = 0.658 | p = 0.400 | |
| n = 2114 | n = 1011 | n = 1099 | |
|
| |||
| ACGA positive | −0.02 | −0.10 | −0.04 |
| (−0.23; 0.20) | (−0.38; 0.18) | (−0.27; 0.35) | |
| p = 0.887 | p = 0.480 | p = 0.804 | |
| n = 1610 | n = 740 | n = 870 | |
Data presented in bold represents significant results. Data presented in italics represents results approaching significance. 95% CI: 95% confidence interval; Ref: reference; ANA: anti-nuclear autoantibodies; Anti-ENA autoantibodies: anti-extractable nuclear antigen autoantibodies; ANCA: anti-neutrophil cytoplasmic autoantibodies; Anti-TPO: anti-thyroid peroxidase autoantibodies; Anti-RHF: anti-rheumatoid factor autoantibodies; Anti-TTG: anti-tissue transglutaminase autoantibodies; Anti-CCP: anti-cyclic citrullinated peptide autoantibodies; ACGA: anti-cardiolipin immunoglobulin G autoantibodies; BMI: body mass index; PA: physical activity; TARFS: Total Australian Recommended Food Score.