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. 2017 Dec 8;20(3):300–305. doi: 10.4103/aja.aja_55_17

Figure 3.

Figure 3

The effects of ASIC1a on the levels of neurogenic inflammation-related factors in the dorsal horn neurons of rat spinal cord. (a) The transfection efficiency of si-ASIC1a was determined by Western blotting analysis. The effects of ASIC1a knockdown on the levels of (b) TNF-α, (c) IL-2, (d) IL-6, (e) IL-10, and (f) IFN-γ in the acid-treated dorsal horn neurons, which were comparable to the results from the acid-treated dorsal horn neurons treated with PcTx-1. *P < 0.05, si-ASIC1a group or the acid-treated group (pH 6.0) versus control; and #P < 0.05, pH 6.0+ si-ASIC1a group or pH 6.0+ PcTx-1 group versus the acid-treated group (pH 6.0). ASICs: acid-sensing ion channels; TNF: tumor necrosis factor; IL: interleukin; IFN: interferon.