Skip to main content
. 2017 Dec 8;20(3):300–305. doi: 10.4103/aja.aja_55_17

Figure 4.

Figure 4

The effects of ASIC1a on the activity of the p38/MAPK signaling pathway in the dorsal horn neurons of rat spinal cord. (a) The protein expression of p-p38 in the acid-treated dorsal horn neurons was significantly increased in a time-dependent manner. (b) The protein expression of p-p38 was significantly decreased in the acid-treated dorsal horn neurons in the presence of the ASIC1a antagonist PcTx-1. (c) The protein expression of p-p38 in the acid-treated dorsal horn neurons was significantly decreased in the presence of the Ca2+ chelator BAPTA-AM or p38-MAPK inhibitor (SB203580). *P < 0.05, acid-treated group (pH 6.0) versus control; and #P < 0.05, pH 6.0+ PcTx-1 group or pH 6.0+ BAPTA-AM group or pH 6.0+ SB203580 versus acid-treated group (pH 6.0).