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. 2017 Dec 8;20(3):300–305. doi: 10.4103/aja.aja_55_17

Figure 5.

Figure 5

The Ca2+ chelator BAPTA-AM, p38-MAPK inhibitor SB203580, or ASIC1a antagonist PcTx-1 significantly decrease the levels of neurogenic inflammation-related factors in the acid-treated dorsal horn neurons. Ca2+ chelator BAPTA-AM, p38-MAPK inhibitor SB203580, or ASIC1a antagonist PcTx-1 significantly decreased the levels of neurogenic inflammation-related factors (a) TNF-α, (b) IL-6, (c) IL-10, and (d) IFN-γ in the acid-treated dorsal horn neurons. *P < 0.05, acid-treated group (pH 6.0) versus control; and #P < 0.05, pH 6.0+ BAPTA-AM group or pH 6.0+ SB203580 or pH 6.0+ PcTx-1 group versus the acid-treated group (pH 6.0). ASICs: acid-sensing ion channels; TNF: tumor necrosis factor; IL: interleukin; IFN: interferon.