Table 4.
In vivo efficacy of the lead molecules from the Stasis Box. Effect on worm burden of a single 200 mg/kg oral dose of nine lead molecules identified after screening the Stasis Box in vitro administered to mice harbouring a 49-day-old adult S. mansoni infection
| Compound | Mice testedn | Mean worm burden ± SD | WBR (%) |
|---|---|---|---|
| MMV690732 | 41 | 47.5 ± 24.3 | 0 |
| MMV690599 | 31 | 44.7 ± 29.6 | 3.2 |
| MMV690787 | 41 | 48.3 ± 21.6 | 0 |
| MMV003452 | 41 | 40.5 ± 17.2 | 12.2 |
| MMV690596 | 41 | 52.0 ± 22.7 | 0 |
| MMV690684 | 41 | 41.5 ± 16.5 | 10.0 |
| MMV690765 | 31 | 84.0 ± 56.4 | 0 |
| MMV690466 | 42 | 10.3 ± 6.9 | 35.9 |
| MMV690534 | 42 | 7.8 ± 7.5 | 51.6 |
| Control1 | 8 | 46.1 ± 21.9 | |
| Control2 | 2 | 16.0 ± 19.8 |
n Indicates the mice control batch. One mouse died prematurely because of toxic effects of MMV690646 (Ispinesib) and therefore data is not shown