Figure 1.

(a) Normal saline-treated group; liver showing normal architecture. (b and c) Acetaminophen-induced liver toxicity group; Liver exhibited severe centrilobular hepatic necrosis, fatty changes, ballooning degeneration, and inflammatory cell infiltration. (d) Acetaminophen + N-acetylcysteine group; showing hepatocytes are normal with slightly congested central vein, mild fatty change, moderate inflammation, and a remarkably reduction in necrosis while other alterations are seen as in acetaminophen group. (e) Acetaminophen + metadoxine 200 mg/kg group, showing the hepatocytes are normal with slightly congested central vein, mild inflammation, mild fatty change, and notable reductions in necrosis while other alterations are similar to acetaminophen group. (f) Acetaminophen and metadoxine 400 mg/kg group, showing the hepatocytes are normal with slightly congested central vein, mild vacuolization around central vein, and a considerable reduction in necrosis and inflammation. H and E, ×20 magnification was used with the exception of picture C for which magnification of ×40 was applied