Table 1.

Insulin sensitivity, estimated using QUICKI, in low and high fat-fed mice treated with three consecutive once-daily doses of vehicle, or 30, 50, or 75 mg/kg STZ.

Diet	Treatment	n	QUICKI
Low fat	Vehicle	4	0.331 ± 0.010
	30 mg/kg STZ	4	0.318 ± 0.021
	50 mg/kg STZ	3	0.301 ± 0.030
High fat	Vehicle	4	0.256 ± 0.007∗
	30 mg/kg STZ	3	0.274 ± 0.009∗
	50 mg/kg STZ	6	0.292 ± 0.008∗
	75 mg/kg STZ	3	0.295 ± 0.016

QUICKI = 1/[log(I₀) + log(G₀)], where I₀ is fasting insulin and G₀ is fasting glucose. Data are means ± SEM. ^∗p < 0.05 versus low-fat vehicle.