Table 2.
Tissue optical properties, correction factors, mean Photofrin concentration, light fluence at 3mm below surface, PDT dose at surface and 3 mm below surface for 8 patients. The light fluence on surface is the same at 60 J/cm2 for all patients.
| Patient | Site | Optical Properties |
CFp | CFa† | Mean Photofrin Concentration (mg/kg) |
Light fluence at 3mm (J/cm2) |
PDT dose at surface (µMJ/cm2) |
PDT dose at 3mm (µMJ/cm2) |
|
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| μa (cm−1) |
μs’ (cm−1) |
||||||||
|
| |||||||||
| #007 | AS | 0.24 | 11.6 | 0.89 | 0.87 | 3.22 ± 0.35 | 73.7 | 318.8 ± 34.7 | 391.8 ± 42.6 |
| PS | 0.37 | 16.6 | 0.89 | 0.68 | 2.94 ± 0.12 | 48.1 | 291.1 ± 11.9 | 233.5 ± 9.5 | |
|
| |||||||||
| #008 | Apex | 0.32 | 7.7 | 1.39 | 1.47 | 4.71± 0.15 | 77.4 | 466.3 ± 14.9 | 601.7 ± 19.2 |
| PCW | 0.16 | 9.1 | 0.84 | 0.93 | 3.47 ± 0.42 | 94.0 | 343.5 ± 41.6 | 538.2 ± 65.1 | |
|
| |||||||||
| #012 | Apex | 0.12 | 14.7 | 0.61 | 0.51 | 3.12 ± 0.35 | 87.4 | 308.9 ± 34.7 | 449.8 ± 50.5 |
| PM | 0.24 | 13.1 | 0.83 | 0.76 | 5.65 ± 0.67 | 69.7 | 559.4 ± 66.3 | 650.1 ± 77.1 | |
|
| |||||||||
| #014 | Peri | 0.09 | 12.5 | 0.59 | 0.56 | 1.87 ± 0.31 | 100.7 | 185.1 ± 30.7 | 310.6 ± 51.5 |
| PS | 0.15 | 13.4 | 0.68 | 0.61 | 3.01 ± 0.05 | 83.7 | 298.0 ± 5.0 | 415.7 ± 6.9 | |
|
| |||||||||
| #016 | Apex | 0.08 | 7.1 | 0.71 | 0.83 | 1.13 ± 0.02 | 119.1 | 111.9 ± 2.0 | 221.9 ± 3.9 |
| PCW | 0.09 | 11.9 | 0.60 | 0.59 | 1.47 ± 0.20 | 102.1 | 145.5 ± 19.8 | 247.8 ± 33.7 | |
|
| |||||||||
| #017 | ACW | 0.33 | 12.4 | 1.00 | 0.95 | 2.80 ± 0.27 | 61.2 | 277.2 ± 26.7 | 282.9 ± 27.3 |
| Apex | 0.42 | 9 | 1.46 | 1.52 | 3.27 ± 0.71 | 63.5 | 323.7 ± 70.3 | 342.7 ± 74.4 | |
| PCW | 0.26 | 8.8 | 1.11 | 1.18 | 1.58 ± 0.21 | 80.1 | 156.4 ± 20.8 | 208.7 ± 27.7 | |
| PM | 0.24 | 10.9 | 0.92 | 0.93 | 3.62 ± 0.61 | 75.8 | 358.4 ± 60.4 | 452.6 ± 76.3 | |
|
| |||||||||
| #018 | ACW | 0.72 | 5.9 | 3.13 | 3.13 | 9.38 ± 0.57 | 57.4 | 928.6 ± 56.4 | 887.7 ± 53.9 |
| Apex | 0.44 | 5.8 | 2.18 | 2.21 | 7.19 ± 0.92 | 74.9 | 711.8 ± 91.1 | 888.6±113.7 | |
| PCW | 0.7 | 7.4 | 2.48 | 2.61 | 5.23 ± 0.47 | 52.1 | 517.8 ± 46.5 | 449.7 ± 40.4 | |
| PS | 0.44 | 5.9 | 2.15 | 2.18 | 5.73 ± 0.24 | 74.4 | 567.3 ± 23.8 | 703.8 ± 29.5 | |
|
| |||||||||
| #020 | Apex | 0.27 | 9 | 1.12 | 1.18 | 4.56 ± 0.45 | 78.1 | 451.4 ± 44.6 | 587.9 ± 58.0 |
| PCW | 0.32 | 10.9 | 1.08 | 1.07 | 2.32 ± 0.23 | 66.4 | 229.7 ± 22.8 | 254.3 ± 25.2 | |
| PS | 0.57 | 9 | 1.79 | 1.88 | 3.54 ± 0.16 | 53.3 | 350.6 ± 15.8 | 311.1 ± 14.1 | |
| PM | 0.33 | 8.5 | 1.31 | 1.38 | 6.81 ± 0.35 | 73.4 | 674.2 ± 34.7 | 824.3 ± 42.4 | |
†
CFa = ((P1+P2 μs’)/μs’)exp((S1+S2 μs’)μeff) (Sharikova et al., 2013; Kim et al., 2016a; Qiu et al., 2016; Penjweini et al., 2016; Kim et al., 2017b); where P1 = 3.881; P2 = 0.0103; S1 = 0.5043; S2 = −0.01622.