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. 2018 May 3;24:2735–2743. doi: 10.12659/MSM.907514

Figure 4.

Figure 4

Effect of AZD8055 in combination with 5-FU on the growth of HCC xenografts in vivo. (A) The image showed the tumor size of SMMC7721 xenografts after 2-week treatment with 5-FU in the presence or absence of AZD8055. (B) Tumor volumes were measured and recorded every 3 days from initial treatment to tumor harvest. (C) Representative pictures of proliferative cells stained with Ki-67 in tumor tissues. (D) The bar graph shows the mean ±SD of quantification of Ki-67-positive cells from immunohistochemical analysis of tumors. (E) The image showed the body weight of SMMC7721 xenografts treatment with 5-FU in the presence or absence of AZD8055 at the end of the experiment. * P<0.05 and ** P<0.01 versus control. Scale bars: 50 um.