Table 3.
Univariate and multivariate analysis of prognostic factors for duodenal GISTs
| Prognostic factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| β | Hazard ratio (95% CI) | P value | β | Hazard ratio (95% CI) | P value | |
| DFS | ||||||
| Age | 0.480 | 1.616 (0.874–2.987) | 0.126 | |||
| Gender | −0.148 | 0.862 (0.470–1.582) | 0.632 | |||
| Anatomical location | 0.108 | 1.114 (0.744–1.666) | 0.601 | |||
| Surgical procedure | 1.517 | 4.559 (2.510–8.281) | < 0.001 | |||
| Tumor size | 1.441 | 4.224 (2.769–6.442) | < 0.001 | 1.406 | 4.082 (1.979–8.416) | < 0.001 |
| Mitotic index | 2.049 | 7.759 (3.751–16.048) | < 0.001 | 1.294 | 3.648 (1.375–9.680) | 0.009 |
| NIH risk category | 1.457 | 4.294 (2.394–7.702) | < 0.001 | |||
| Adjuvant therapy | 0.327 | 1.387 (0.514–3.742) | 0.518 | |||
| DSS | ||||||
| Age | 0.338 | 1.403 (0.596–3.300) | 0.438 | |||
| Gender | 0.324 | 1.383 (0.587–3.257) | 0.459 | |||
| Anatomical location | 0.107 | 1.113 (0.649–1.909) | 0.697 | |||
| Surgical procedure | 1.082 | 2.952 (1.274–6.837) | 0.012 | |||
| Tumor size | 1.629 | 5.100 (2.640–9.853) | < 0.001 | 1.339 | 3.816 (1.743–8.354) | 0.001 |
| Mitotic index | 1.719 | 5.580 (2.277–13.674) | < 0.001 | |||
| NIH risk category | 1.035 | 2.815 (1.547–5.123) | 0.001 | |||
| Adjuvant therapy | −1.388 | 0.249 (0.033–1.877) | 0.178 | |||
GIST: gastrointestinal stromal tumor; NIH: National Institutes of Health;
DFS: disease-free survival; DSS: disease-specific survival; CI: confidence interval