Table 3.
Eight metabolite concentrations in severe CAP and non-severe CAP patients of the validation cohort
| Metabolite | Concentration (μg/ml) | p value | Tendency | |
|---|---|---|---|---|
| SCAP (n = 19) | NSCAP (n = 32) | |||
| Sphinganine | 0.041 (0.028–0.050) | 0.022 (0.012–0.028) | < 0.001 | Controls > SCAP > NSCAP |
| Creatine | 5.420 (3.447–8.711) | 2.481 (1.739–3.767) | < 0.001 | SCAP > controls > NSCAP |
| l-Arginine | 5.043 (4.105–5.753) | 5.905 (4.622–7.047) | 0.016 | NSCAP > SCAP > controls |
| Lactate | 141.343 (120.670–273.794) |
107.224 (86.814–137.551) |
0.001 | SCAP > NSCAP > controls |
| l-Acetylcarnitine | 0.076 (0.029–0.225) | 0.063 (0.042–0.098) | 0.667 | Controls > SCAP > NSCAP |
| Glycerophosphocholine | 4.438 (2.596–8.170) | 5.732 (3.048–7.212) | 0.181 | Controls > NSCAP > SCAP |
| DHEA-S | 0.370 (0.229–0.425) | 0.532 (0.379–0.812) | < 0.001 | Controls > NSCAP > SCAP |
| p-Cresol sulfate | 0.109 (0.004–0.801) | 0.073 (0.012–0.203) | < 0.001 | Controls > SCAP > NSCAP |
Data presented as median (interquartile range)
CAP community-acquired pneumonia, SCAP severe CAP, NSCAP non-severe CAP, DHEA-S dehydroepiandrosterone sulfate