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. 2018 May 14;15:142. doi: 10.1186/s12974-018-1166-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Transcriptomic profiling of neurovascular unit after LPS challenge. a Expression profile of cell type-specific makers in neurovasculature preparation. b Volcano plot of statistically significant upregulated (green) and downregulated (red) genes in the neurovascular unit after LPS challenge. c Gene ontology clusters for up- and downregulated genes identified using DAVID bioinformatics resource. Neurovasculature was isolated 4 h post last LPS dose. Data are means ± SEM, n = 4/5 mice per group