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. 2018 May 14;15:142. doi: 10.1186/s12974-018-1166-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Pharmacokinetic and pharmacodynamic profiling of CPD-4645 in naïve mouse brain. a Structure of the 2-AG hydrolysis inhibitor CPD-4645. Total CPD-4645 concentrations in brain and plasma (b) and bulk levels of brain 2-AG (c) and AA (d) at given time points following single 10 mg/kg subcutaneous dose of CPD-4645 in CD1 mice. Data are means ± SEM, n = 3/5 mice per group