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. 2018 May 14;15:142. doi: 10.1186/s12974-018-1166-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Pharmacodynamic and anti-inflammatory activity of CPD-4645 in LPS-challenged mouse brain. Inhibition of MAGL by CPD-4645 resulted in significant elevation of brain 2-AG (a) and concomitant reduction in brain AA (b). Levels of the proinflammatory cytokines, IL1β (c) and IL6 (d), were significantly modulated in brain tissue following LPS challenge and CPD-4645 treatment. Bar graphs were plotted with mean ± SEM and data analyzed using one-way analysis of variance (ANOVA) with Bonferroni post-hoc comparisons. n = 10 mice per group. Significance is shown as *p < 0.05; **p < 0.01; ****p < 0.0001