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. 2018 May 14;15:142. doi: 10.1186/s12974-018-1166-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Genes related to BBB (dys) function and proteases are differentially expressed after LPS challenge and treatment with CPD-4645. a Changes in the expression of 40 genes related to BBB function and dysfunction. The y-axis represents the log2-fold change due to LPS challenge while the x-axis represents the log2-fold change due to CPD-4645 treatment. Dotted line represents a return to basal expression level. Size of the bubbles represents the multiple comparison adjusted p values for vehicle vs. CPD-4645 treatment. b Expression levels of selected BBB genes. c Expression levels of selected extracellular proteases. n = 4–5 mice/group. Significance is shown as adjusted p values *p ≤ 0.05, **p < 0.01, *** p < 0.001. Differential gene expression was analyzed using the limma package in R/Bioconductor (see Methods)