Fig. 7.

CPD-4645 rescues BBB integrity after ischemic challenge. The rose bengal photothrombosis model induces a focal ischemic injury that leads to BBB dysfunction. CPD-4645 administered 30 min post lesion (a, b) reduced the penumbra size (a) and BBB permeability (b) as assessed by extravasation of Cadavarin⁵⁵⁵ into the brain parenchyma. CPD-4645 administered 6 h post ischemic lesion (c, d) reduces penumbra size (c) and BBB permeability (d) as assessed by extravasation of 70 kDa FITC conjugated dextran in the brain parenchyma. Data were plotted with means ± SEM and data analyzed using unpaired t test (n = 5 mice/group). Significance is shown as *p ≤ 0.05 and **p < 0.01 compared to vehicle group