Fig. 2.

Genetic ablation of Ripk3 sustained cardiac function after IR injury (n = 6/group). (A–C) Content of cardiac damage markers, including LDH, Troponin T, and CK-MB. (D–F) Cardiac function is evaluated through echocardiography. Quantitative analysis of the data derived from echocardiography. (G) Resting cell length. (H) Peak shortening (normalized to cell length). (I) Maximal velocity of shortening (+ dL/dt). (J) Maximal velocity of relengthening (− dL/dt). (K) Time-to-peak shortening (TPS). (L) Time-to-90% relengthening (TR₉₀). (M) TEM was used to observe the ultrastructural changes after IR injury in vivo. *P < 0.05 vs the sham group; ^#P < 0.05 vs IR+WT group.