Demographics of patients with type emm74 invasive disease in Canada and source of isolation of invasive emm74 group A Streptococcus invasive strains responsible for these infections. A, Age and sex of patients with emm74 iGAS disease in Canada for the period January 2012 to June 2017. Sex data were unavailable for 4 patients, and age was unavailable for 1 (indicated by NA). Overall, the distribution indicates that emm74 iGAS disease disproportionately affects adult middle-aged or older males. B, Anatomical source of isolation of the 168 emm74 iGAS isolates. Data are shown as percentage of the total number of isolates. The majority (n = 114, 67.9%) of isolates were recovered from blood, followed by abscesses and soft tissue (n = 32, 19%), synovial fluid (n = 11, 6.5%), peritoneal fluid (n = 3, 1.8%), and pleural fluid (n = 3, 1.8%). Five isolates (3%) were recovered from undetermined aspirates or from surgical specimens, collectively defined as “other” in the figure legend.